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Tohoku University Technology: New method for screening mitochondrial function-enhancer: T17-024

Tohoku University Technology: New method for screening mitochondrial function-enhancer: T17-024

Drug-screening method based on new regulatory mechanism of mitochondria & the products

CNS degenerative disorders, including AD and PD, are increasingly believed to be caused due to mitochondrial disability leading to neuronal death. This inventor recently identified a novel intracellular regulatory factor XXX in the CNS neurons that contributes to mitochondrial homeostasis, and the inventor further developed a method for screening beneficial ability of chemicals to enhance mitochondrial function due to elevation of the XXX level.

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Tohoku Univ. Technology：Immunosuppressant/Weight gain inhibitor：T12-045

Tohoku Univ. Technology：Immunosuppressant/Weight gain inhibitor：T12-045

Compound derived from slime mold having Immunosuppressive action and weight gain inhibitory action and its derivative

　Previously, Ppc1, a small molecule compound derived from a cellular slime mold, was only known to inhibit the growth of cultured cells.　 　We have demonstrated that Ppc1 and its derivatives have inhibitory and uncoupling effects on IL-2 production.

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Muroran Inst. Technology：Small Molecules Repeatedly Dissolved and Turbid in Water in Response to Ambient Temperature：MU24-002

Muroran Inst. Technology：Small Molecules Repeatedly Dissolved and Turbid in Water in Response to Ambient Temperature：MU24-002

Small Molecules Repeatedly Dissolved and Turbid in Water in Response to Ambient Temperature

　There are known compounds that exhibit phase separation when solutes dissolved in solvents exceed a certain temperature (LCST). Poly (N-isopropylacrylamide) (PNIPAm) has been studied as a representative of these compounds, and applications to temperature-responsive smart windows have been reported. However, since the LCST of PNIPAm is constant at 31°C, a compound that can flexibly respond to the LCST depending on ambient temperature has been desired in industry. 　The inventors succeeded in synthesizing a new compound. This compound is characterized by the ability to control the LCST within the range of about 25~55°C by modifying a part of its structure. When applying to smart windows, most of them require a power supply because they switch between transmission and non-transmission by turning the voltage on and off. On the other hand, smart windows using this compound can be used in places without a power supply because they switch between transmission and non-transmission spontaneously according to changes in the outside temperature. Furthermore, by controlling the heat according to the degree of light transmission, it is expected to be effective against heat.

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